cyclophosphamide will increase the stage or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
In animal research, the median lethal dose (LD50) of modafinil varies amongst species and will depend on the route of administration. In mice and rats, the LD50 is approximately 1250 mg/kg if administered through an injection, but the oral LD50 for rats is 3400 mg/kg.
In OSA, PROVIGIL is indicated to take care of too much sleepiness and never as remedy for the fundamental obstruction. If constant favourable airway pressure (CPAP) may be the therapy of option for a client, a maximal energy to treat with CPAP for an sufficient timeframe should be produced before initiating and during procedure with PROVIGIL for extreme sleepiness.
indinavir will increase the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
apalutamide will lower the extent or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicine which are CYP3A4 substrates may result in lower exposure to those drugs.
modafinil will boost the level or outcome of clobazam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Dosage adjustment can be demanded; CYP2C19 inhibitors could result in enhanced publicity to N-desmethylclobazam (active metabolite).
mitotane decreases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Mitotane is a powerful inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for possible dosage adjustments.
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Medication that demand prior authorization. This restriction calls for that certain medical conditions be fulfilled before the approval of your prescription.
In order to obtain a prescription for modafinil, click here a affected individual will need to have a valid health care cause of utilizing the drug, for example narcolepsy or sleep apnea. Additionally, the prescription need to be penned by a accredited physician and loaded at a licensed pharmacy. Using modafinil for non-health care needs, for example Together with the purpose to boost cognitive effectiveness or to remain awake for prolonged periods of time, is strictly prohibited and can lead to authorized outcomes.[one hundred seventy five][176] Europe[edit]
Heart problems: In individuals with preexisting cardiovascular circumstances, consider enhanced monitoring. Modafinil will not be proposed in sufferers with documented left-ventricular hypertrophy or maybe a historical past of the earlier cardiotoxicity associated with psychostimulant use.
Steer clear of or substitute another drug for these medicines when feasible. Evaluate for lack of therapeutic result if medication should be coadministered.
primidone will lessen the extent or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
In 2008, Cephalon paid out $425m and pleaded responsible into a federal prison cost concerning its marketing of off-label uses for Provigil and two other medications. ^